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Also, we didn't account for correlations across design parameters in Monte Carlo simulations, an element which will have amplified the spread of simulated blood PFAS amounts (Burmaster and Anderson 1994). The assumptions the initial plasma PFAS amount is at continual condition and that PFAS ingestion over a overall body body weight foundation is continual throughout pregnancy might oversimplify variants which have been anticipated to happen The truth is.
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To assess product accuracy, we simulated maternal plasma PFAS levels based upon the very first of the two serial measurements of PFAS from two printed studies (Glynn et al. seo consultant jobs 2012; Monroy et al. 2008) and visually in contrast simulated profiles with observed ranges (Determine two).
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. We evaluated the affect of different assumptions about the association concerning PBPK-derived PFAS concentrations and beginning body weight. Together with analyses famous previously mentioned, we ran many Monte Carlo simulations with different parameters for PFAS distributions (larger and lower suggests and common deviations) and various coefficients for that GFR–birth pounds association. Specifically, we halved or doubled these 3 parameters, one at a time. We also ran Monte Carlo simulations with unique sampling seeds To judge reproducibility.
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